首页>研究单元>中国科学院合成生物学重点实验室>研究成果>发表文章>2016

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  1. Gao X, Gao F, Liu D, Zhang H, Nie XQ, Yang C*. (2016) Engineering the methylerythritol phosphate pathway in cyanobacteria for photosynthetic isoprene production from CO2. Energy Environ Sci, 9:1400-1411.
  2. Wang JF, Li SY, Xiong ZQ, Wang Y*. (2016) Pathway mining-based integration of critical enzyme parts for de novo biosynthesis of steviolglycosides sweetener in Escherichia coli. Cell Res, 26,258-261.
  3. Qi X, Lin W, Ma M, Wang C, He Y, He N, Gao J, Zhou H, Xiao Y, Wang Y, Zhang P*. (2016) Structural basis of rifampin inactivation by rifampin phosphotransferase. Proc Natl Acad Sci USA, 113(14):3803-3808.
  4. Zhou JT, Wu RH, Xue XL*, Qin ZJ*. (2016) CasHRA (Cas9-facilitated Homologous Recombination Assembly) method of constructing megabase-sized DNA. Nucleic Acids Research, 44(14):e124
  5. Yang C, Gao X, Jiang Y, Sun BB, Gao F and Yang S*. (2016) Synergy between methylerythritol phosphate pathway and mevalonate pathway for isoprene production in Escherichia coli. Metab Eng, 37:79-91.
  6. Yang YP, Lang NN, Yang GH, Yang S, Jiang WH* and Gu Y*. (2016) Improving the performance of solventogenic clostridia by reinforcing the biotin synthetic pathway. Metab Eng, 35:121-128.
  7. Yang C, Gao X, Jiang Y, Sun BB, Gao F, Yang S*. (2016) Synergy between methylerythritol phosphate pathway and mevalonate pathway for isoprene production in Escherichia coli. Metab Eng, 37:79-91.
  8. Yu Y, Zhou H, Kong Y, Pan B, Chen L, Wang H, Hao P* and Li X*. (2016) The landscape of A-to-I RNA editome is shaped by both positive and purifying selection. PLoS Genetics, 12(7):e1006191.
  9. Zhou YQ, Li WC, Zhang XX, Zhang HB, Xiao YL*. (2016) Global profiling of cellular targets of gambogic acid by quantitative chemical proteomics. Chem Commun, Nov 29;52(97):14035-14038.
  10. Zhao C, Gao X, Liu X, Wang Y, Yang S, Wang FQ*, Ren YH* (2016) Enhancing Biosynthesis of a Ginsenoside Precursor by Self-Assembly of Two Key Enzymes in Pichia pastoris. J Agric Food Chem, 64(17):3380-5.
  11. Ren C, Wen Z, Xu Y, Jiang WH* and Gu Y*. (2016) Clostridia: a flexible microbial platform for the production of alcohols. Curr Opin Chem Biol, 35:65-72.
  12. Li SY, Zhao GP*, Wang J*. (2016) C？Brick: A New Standard for Assembly of Biological Parts Using Cpf1. ACS Synthetic Biology, 5(12):1383-1388.
  13. Huang H, Chai CS, Li N, Rowe P, Minton NP, Yang S, Jiang WH and Gu Y*. (2016) CRISPR/Cas9-based efficient genome editing in Clostridium ljungdahlii, an autotrophic gas-fermenting bacterium. ACS Synth Biol, Dec 16;5(12):1355-1361.
  14. Zhang Q, Zhou A, Li S, Ni J, Tao J, Lu J, Wan B, Li S, Zhang J, Zhao S, Zhao GP, Shao F, Yao YF*. (2016) Reversible lysine acetylation is involved in DNA replication initiation by regulating activities of initiator DnaA in Escherichia coli. Sci Rep, Aug 3;6:30837.
  15. Xu YH, Zhu YZ, Wang YZ, Chang YF, Zhang Y, Jiang XG, Zhuang XR, Zhu YQ, Zhang JL, Zeng LB, Yang MJ, Li SJ, Wang SY, Ye Q, Xin XF, Zhao GP, Zheng HJ*, Guo XK*, Wang JZ*. (2016) Whole genome sequencing revealed host adaptation-focused genomic plasticity of pathogenic Leptospira. Sci Rep, 6:20020
  16. Zhou YQ#, Li WC#, Xiao YL*. (2016) Profiling of Multiple Targets of Artemisinin Activated by Hemin in Cancer Cell Proteome. ACS Chem Biol, 11(4):882-888.
  17. Li WC#, Zhou YQ#, Tang GH, Xiao YL*. (2016) Characterization of the artemisinin binding site for translationally controlled tumor protein (TCTP) by bioorthogonal click chemistry. Bioconjugate Chem, Dec 21;27(12):2828-2833.
  18. He JM, Zhu H, Zheng GS, Liu PP, Wang J, Zhao GP, Zhu GQ*, Jiang WH* and Lu YH*. (2016) Direct invovlement of the master nitrogen metabolism regulator in antibiotic biosynthesis in Streptomyces. J Biol Chem, Dec 16;291(51):26443-26454.
  19. Li Q, Chen J, Minton NP, Zhang Y, Wen ZQ, Liu JL, Yang HF, Zeng Z, Ren XD, Yang JJ, Gu Y, Jiang WH, Jiang Y and Yang S*. (2016) CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii. Biotechnol J, 11(7):961-72.
  20. Jiang Y, Tao RS and Yang S*. (2016) Tailor-made biocatalysts enzymes for the fine chemical industry in China. BiotechnolJ. 11:1121–1123.
  21. Meng HL, Xiong ZQ，Song SJ, Wang JF, Wang Y*. (2016) Construction of polyketide overproducing E. coli strains via synthetic antisense RNAs based on in silicofluxome analysis and comparative transcriptome analysis. Biotechnol J, 11(4):530-541.
  22. Chen L, Zou G, Wang JZ, Wang J, Liu R, Jiang YP, Zhao GP, Zhou ZH*. (2016) Characterization of the Ca2+-responsive signaling pathway in regulating the expression and secretion of cellulases in Trichoderma reesei Rut-C30. Molecular Microbiology, 100:560-575.
  23. Nie XQ, Yang B, Zhang L, Gu Y, Yang S, Jiang WH, Yang C*. (2016) PTS regulation domain-containing transcriptional activator CelR and sigma factor σ54 control cellobiose utilization in Clostridium acetobutylicum. Molecular Microbiology, 100(2):289-302.
  24. Lv HJ, Li JH, Wu YY, Garyali S, Wang Y*. (2016) Transporter and its engineering for secondary metabolites. Appl Microbiol Biotechnol, 100(14):6119-6130.
  25. Xue Q, Yang YP, Chen J, Chen L, Yang S, Jiang WH* and Gu Y*. (2016) Roles of three AbrBs in regulating two-phase Clostridium acetobutylicumfermention. Appl Microbiol Biotechnol, Nov;100(21):9081-9089.
  26. Gao SL, Tong YY, Wen ZQ, Zhu L, Ge M, Chen DJ*, Jiang Y* and Yang S*. (2016) Multiplex gene editing of the Yarrowialipolytica genome using the CRISPR-Cas9 system. J Ind Microbiol Biotechnol, 43(8):1085-1093.
  27. LiuYM,YangJJ, JiangY and Yang S*. (2016) Complete genome sequence of nucleoside producing strain CorynebacteriumstationisATCC 6872. J Biotechnol, 225(10):57-58.
  28. Tong J, Meng L, Wang X, Liu L, Lyu L, Wang C, Li Y, Gao Q, Yang C*, Niu C*. (2016) The FBPase Encoding Gene glpX Is Required for Gluconeogenesis, Bacterial Proliferation and Division In Vivo of Mycobacterium marinum. PloS One, 11(5):e0156663.
  29. Xu XS, Chen J, Wang QZ, DuanCL, Li Y, Wang RX and Yang S*. (2016) Mutagenesis of key residues in the binding center of l-aspartate-b-semialdehydedehydrogenase from Escherichia coli enhances utilization of the cofactor NAD(H). Chem Bio Chem, 17:56-64.
  30. Zhou YQ, Li WC, Wang ML, Zhang XX, Zhang HB, Tong XF, Xiao YL*. (2016) Competitive profiling of celastrol targets in human cervical cancer HeLa cells via quantitative chemical proteomics. Mol BioSyst, Dec 20;13(1):83-91.
  31. Peng SY, Chu ZM, Lu JF, Li DX, Wang YH, Yang SL, Zhang Y*. (2016) Co-expression of chaperones from P. furiosus enhanced the soluble expression of the recombinant hyperthermophilic α-amylase in E. coli. Cell Stress Chaperones, May;21(3):477-84.
  32. Cen XF, Wang JZ, Zhao GP, Wang Y*, Wang J*. (2016) Molecular evidence for the coordination of nitrogen and carbon metabolisms, revealed by a study on the transcriptional regulation of the agl3EFG operon that encodes a putative carbohydrate transporter in Streptomyces coelicolor. Biochem Biophys Res Commun, 471:510-514.
  33. Xu G, Jiang Y, Tao RS, Wang SF, Zeng H and Yang S*. (2016) A recyclable biotransformation system for L-2-aminobutyric acid production based on immobilized enzyme technology. Biotechnol Lett, 38(1):123-9.
  34. Jiang Y ,Tao RS, Shen ZQ, Sun LD, Zhu FY and Yang S*. (2016) Enzymatic production of glutathione bybifunctional γ-glutamylcysteinesynthetase/glutathione synthetasecoupled with in vitro acetate kinase-based ATP generation. Appl Biochem Biotechnol, 180(7):1446-1455.
  35. Meng L，Xiong Z，Chu J, Wang Y*. (2016) Enhanced production of avermectin by deletion of type III PKSs biosynthetic cluster rpp in Streptomyces avermitilis. Lett Appl Microbiol, 63(05):384-390.
  36. Zhang Y, Xu S, Chai CS, Yang S, Jiang WH, Minton NP and Gu Y*. (2016) Development of an inducible transposon system for efficient random mutagenesis in Clostridium acetobutylicum. FEMS MicrobiolLett, 363(8). pii: fnw065.
  37. Chen SS, Zheng GS, Zhu H, He HQ, Chen L, Zhang WW, Jiang WH and Lu YH*. (2016) Roles of two-component system AfsQ1/Q2 in regulating biosynthesis of the yellow-pigmented coelimycin P2 in Streptomyces coelicolor. FEMS MicrobiolLett, 363(15). pii: fnw160.
  38. Wang QZ, Tang SY* and Yang S*. (2016) Genetic biosensors for small-molecule products: design and applications in high-throughput screening. Front Chem Sci Eng, (In Press).
  39. Li JH, M HL, Wang Y*. (2016) Synbiological systems for complex natural products biosynthesis, Synthetic and Systems Biotechnology, 1(04):221-229.
  40. Li X* , Kong Y, Zhao QY, Li YY, and Hao P*. (2016) De novo assembly of transcriptome from next-generation sequencing data. Quantitative Biology, 4(2):94-105.
  41. Zhao Q-Y*, Gratten J, Restuadi R, and Li X*. (2016) Mapping and differential expression analysis from short-read RNA-Seq data in model organisms. Quantitative Biology, 4(1):22-35.
  42. 曾哲,任晓丹,杨晟*. (2016) 基于基因组编辑技术的大片段克隆新策略[J]. 生物工程学报, 32(4):401-408.
  43. 陶荣盛，范文超，朱傅赟，原犇犇，姜卫红，杨蕴刘，蒋宇，杨晟*. (2016) 生物催化绿色制造精细化学品进展和实例. 上海应用技术学院学报, 6(2):109-111.