个人信息

博士生导师
研究员

Email: lwan@cemps.ac.cn
个人网页:

研究方向

植物分子免疫学

万里

个人简介

2003.9-2007.6 本科 武汉理工大学 生物技术
2007.9-2010.6 硕士 武汉理工大学 应用化学
2010.8-2014.11 博士 澳大利亚昆士兰大学 生物化学与结构生物学
2015.3-2020.1 博士后 美国北卡罗莱纳大学教堂山分校 植物分子免疫学
2020.5-至今 研究员 中科院分子植物科学卓越创新中心 植物分子免疫学

研究工作

植物的免疫系统主要由植物细胞膜上的受体和细胞内的免疫受体组成。在自然界中,病菌实际上只能成功侵染少数种类的植物,对大多数种类的植物不具有致病性,这种天然有效的广谱抗性称之为非宿主抗性。本研究组综合多种研究手段包括植物遗传学和蛋白质结构生物学等以阐明植物细胞内免疫受体工作和非宿主抗性发生的分子机理。

主要成果

    (# 共同一作; * 通讯作者)

    Li Wan * and Zuhua He *. NADase and now Ca2+ channel, what else to learn about plant NLRs Stress Biology 1:7 (2021)

    Pierre Jacob #, Nak Hyun Kim #, Feihua Wu, Farid El-Kasmi, Yuan Chi, William G. Walton, Oliver J. Furzer, Adam D. Lietzan, Sruthi Sunil, Korina Kempthorn, Matthew R. Redinbo, Zhen-Ming Pei *, Li Wan * and Jeffery L. Dangl *. Plant “helper” immune receptors are Ca2+-permeable non-selective cation channels. Science 373: 420-425 (2021).

    Li Wan #, Kow Essuman #, Ryan G. Anderson, Yo Sasaki, Freddy Monteiro, Eui-Hwan Chung, Erin Osborne Nishimura, Aaron DiAntonio, Jeffrey Milbrandt *, Jeffery L. Dang *, Marc T. Nishimura *. TIR Domains of Plant Immune Receptors are NAD+ Cleaving Enzymes that Promote Cell Death. Science 365: 799–803 (2019).

    Li Wan # *, Koeck Markus #, Simon J. Williams, Ashton AR, Lawrence GJ, Sakakibara H, Kojima M, B?ttcher C, Ericsson DJ, Hardham AR, Jones DA, Ellis JG, Bostjan Kobe *, Peter N. Dodds *. Structural and functional insights into the modulation of the activity of a flax cytokinin oxidase by flax rust effector AvrL567-A. Molecular Plant Pathology 20(2): 211-222 (2019).

    Farid El Kasmi #, Eui-Hwan Chung #, Ryan G. Andersona, Jinyue Lic, Li Wan, Timothy K. Eitasd, Zhiyong Gao, and Jeffery L. Dangl *. Signaling from the plasma-membrane localized plant immune receptor RPM1 requires self-association of the full-length protein. PNAS 114(35): E7385-E7394 (2017).

    Erica J. Washington, M. Shahid Mukhtar, Omri M. Finkel, Li Wan, Mark J. Banfield, Joseph J. Kieber, and Jeffery L. Dangl *. Pseudomonas syringae type III effector HopAF1 suppresses plant immunity by targeting methionine recycling to block ethylene induction. PNAS 113(25): E3577-3586 (2016).

    Simon J. Williams #*, Kee Hoon Sohn, #*, Li Wan #, Maud Bernoux #, Panagiotis F. Sarris, Cecile Segonzac, Thomas Ve, Yan Ma, Simon B. Saucet, Daniel J. Ericsson, Lachlan W. Casey, Thierry Lonhienne, Donald J. Winzor, Xiaoxiao Zhang, Anne Coerdt, Jane E. Parker, Peter N. Dodds, Bostjan Kobe *, Jonathan D. G. Jones *.Structural basis for assembly and function of a heterodimeric plant immune receptor. Science 344: 299-303 (2014).