Yinyan Xiao ^#, Xiaoxian Wu ^#, Zaiqing Wang ^#, Kexin Ji, Yang Zhao, Yu Zhang ^*, Li Wan ^*.  Activation and inhibition mechanisms of a plant helper NLR. Nature 639: 438-446 (2025)

Hu Yu ^#, Weiying Xu ^#, Sisi Chen ^#, Xiaoxian Wu, Weiwei Rao, Xiaoxiao Liu, Xiaoyan Xu, Jingqi Chen, Marc Nishimura, Yu Zhang, Li Wan ^*. Activation of a helper NLR by plant and bacterial TIR immune signaling. Science 386: 1413-1420 (2024)

Zaiqing Wang #, Xiaoxiao Liu #, Jie Yu, Shuining Yin, Wenjuan Cai, Nak Hyun Kim, Farid El Kasmi, Jeffery L. Dangl and Li Wan *. Plasma membrane association and resistosome formation of plant helper immune receptors. PNAS 120 (32) e2222036120 (2023)

Pierre Jacob #, Nak Hyun Kim #, Feihua Wu, Farid El-Kasmi, Yuan Chi, William G. Walton, Oliver J. Furzer, Adam D. Lietzan, Sruthi Sunil, Korina Kempthorn, Matthew R. Redinbo, Zhen-Ming Pei *, Li Wan * and Jeffery L. Dangl *. Plant “helper” immune receptors are Ca2+-permeable non-selective cation channels. Science 373: 420-425 (2021)

Weiwei Rao ^#, Tingting Ma ^#, Jiayuan Cao, Yajun Zhang, Sisi Chen, Shu Lin, Xiaoxiao Liu, Guangcun He, Li Wan ^*. Recognition of a salivary effector by the TNL protein RCSP promotes effector-triggered immunity and systemic resistance in Nicotiana benthamiana. J Integr Plant Biol 67: 150-168 (2025)

Jun Li ^#, Sisi Chen ^#, Bo Yu ^#, Qingzhong Li, Ruijia Liu, Zaiqing Wang, Li Wan ^*, Yang Zhao ^* TIR immune signaling is blocked by phosphorylation to maintain plant growth. Nature Plants 11: 1193–1204 (2025)

Adam M. Bayless #, Sisi Chen #, Sam C. Ogden, Xiaoyan Xu, John D. Sidda, Mohammad K. Manik, Sulin Li, Bostjan Kobe, Thomas Ve, Lijiang Song, Murray Grant, Li Wan *, Marc T. Nishimura *. Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products. Science Advances 9: eade8487 (2023)

Li Wan #, Kow Essuman #, Ryan G. Anderson, Yo Sasaki, Freddy Monteiro, Eui-Hwan Chung, Erin Osborne Nishimura, Aaron DiAntonio, Jeffrey Milbrandt *, Jeffery L. Dang *, Marc T. Nishimura *. TIR Domains of Plant Immune Receptors are NAD+ Cleaving Enzymes that Promote Cell Death. Science 365: 799–803 (2019).

Simon J. Williams #*, Kee Hoon Sohn, #*, Li Wan #, Maud Bernoux #, Panagiotis F. Sarris, Cecile Segonzac, Thomas Ve, Yan Ma, Simon B. Saucet, Daniel J. Ericsson, Lachlan W. Casey, Thierry Lonhienne, Donald J. Winzor, Xiaoxiao Zhang, Anne Coerdt, Jane E. Parker, Peter N. Dodds, Bostjan Kobe *, Jonathan D. G. Jones *.Structural basis for assembly and function of a heterodimeric plant immune receptor. Science 344: 299-303 (2014).

综述论文：(# 共同一作; * 通讯作者)

Li Wan *. TIR enzymatic functions: signaling molecules and receptor mechanisms. aBIOTECH 6:58:10 Z (2023)

Weiwei Rao , Li Wan *, Ertao Wang *. Plant immunity in soybean progress, strategies and perspectives. Molecular Breeding 43(6):52 (2023)

Xiaoxiao Liu and Li Wan *. Molecular insights into the biochemical functions and signaling mechanisms of plant NLRs. Molecular Plant Pathology 23(6):772-780 (2022)

Li Wan * and Zuhua He *. NADase and now Ca2+ channel, what else to learn about plant NLRs? Stress Biology 1:7 (2021)

其他论文：(# 共同一作; * 通讯作者)

Yu Yang, Oliver J. Furzer, Eleanor P. Fensterle, Shu Lin, Zhiyu Zheng, Nak Hyun Kim, Li Wan, Jeffery L. Dangl*. Paired plant immune CHS3-CSA1 receptor alleles form distinct hetero-oligomeric complexes. Science 383: eadk3468 (2024)

Yu Yang , Nak Hyun Kim , Volkan Cevik , Pierre Jacob , Li Wan , Oliver J Furzer , Jeffery L Dang *. Allelic variation in the Arabidopsis TNL CHS3/CSA1 immune receptor pair reveals two functional cell-death regulatory modes. Cell Host Microbe 30(12):1701-1716 (2022)

Svenja C. Saile, Frank M. Ackermann, Sruthi Sunil, Jutta Keicher, Adam Bayless, Vera Bonardi, Li Wan, Mehdi Doumane, Eva Stobbe, Yvon Jaillais, Marie-Cécile Caillaud, Jeffery L. Dangl, Marc T. Nishimura, Claudia Oecking, Farid El Kasmi *. Arabidopsis ADR1 helper NLR immune receptors localize and function at the plasma membrane in a phospholipid dependent manner. New Phytologist 232(6):2440-2456 (2021)

Li Wan # *, Koeck Markus #, Simon J. Williams, Ashton AR, Lawrence GJ, Sakakibara H, Kojima M, B?ttcher C, Ericsson DJ, Hardham AR, Jones DA, Ellis JG, Bostjan Kobe *, Peter N. Dodds *. Structural and functional insights into the modulation of the activity of a flax cytokinin oxidase by flax rust effector AvrL567-A. Molecular Plant Pathology 20(2): 211-222 (2019).

Farid El Kasmi #, Eui-Hwan Chung #, Ryan G. Andersona, Jinyue Lic, Li Wan, Timothy K. Eitasd, Zhiyong Gao, and Jeffery L. Dangl *. Signaling from the plasma-membrane localized plant immune receptor RPM1 requires self-association of the full-length protein. PNAS 114(35): E7385-E7394 (2017).

Erica J. Washington, M. Shahid Mukhtar, Omri M. Finkel, Li Wan, Mark J. Banfield, Joseph J. Kieber, and Jeffery L. Dangl *. Pseudomonas syringae type III effector HopAF1 suppresses plant immunity by targeting methionine recycling to block ethylene induction. PNAS 113(25): E3577-3586 (2016).