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个人信息

博士生导师
研究员

Email: yfw@cemps.ac.cn
个人网页: http://people.ucas.edu.cn/~0012230

研究方向

植物离子营养与信号

王永飞

个人简介

1995年7月毕业于河北师范大学生物系，获学士学位
1998年7月毕业于河北师范大学生物系，获硕士学位
2002年7月毕业于中国农业大学生物学院，获博士学位
2003年1月-2008年1月，在UC, San Diego做博士后研究
2008年1月-2009年7月，在UC, San Diego做Staff Research Associate
2009年8月至今在中国科学院上海生命科学研究院植物生理生态研究所工作

研究工作

多种离子物质作为辅酶、信号分子、细胞渗透分子和重要结构组份参与各种生物化学反应、细胞信号传递、细胞运动和结构形成，在植物生长发育、细胞运动和逆境反应中发挥核心作用。因此，研究植物离子营养和信号，解析离子被植物吸收运输，以及参与各种细胞信号传递和逆境反应的分子机理具有重要的科学意义，并可以为农业生产和生态保护提供强有力的知识和技术支撑，具有良好的潜在应用前景。离子通道（ion channels）和离子转运体(ion transporters)是负责介导和调控离子跨膜运动的一大类功能蛋白分子，是解析和研究植物离子营养和信号的核心研究对象，是开展相关研究的重要切入点和着力点。基于此，本研究组以模式植物拟南芥和模式作物水稻为材料，以离子通道和离子转运体为起点和切入点，以国际前沿课题为引领，以国家战略需求为导向，重点开展植物离子营养和信号方面的研究。通过我们的研究，一方面我们可以在植物学基础科学研究方面贡献新知识和新技术，为植物学领域的重要科学问题提供答案，比如植物如何通过调控离子的跨膜运输调控气孔关闭运动，从而实现植物耐旱节水的目的；植物如何利用离子作为主要的渗透物质和信号物质驱动和调控花粉管的极性生长，并精细调控其生长方向，确保双受精的顺利实现；植物如何高效协同地同时利用多种离子通道和转运体实现对多种离子物质的协调高效吸收、体内转运和跨膜运输。另一方面，还可以为国家农业生产、生态保护等提供知识技术支撑。通过多年的积累，本研究组已经取得了一些可喜的进展，相关工作被发表在多个国际知名期刊上。同时，建立了完备的实验体系，形成了较为系统的研究思路。我们欢迎和鼓励年轻的研究生、博士后和工作人员，加入到我们的研究组，共同探索未知、享受科学探索特有的乐趣、分享喜悦、同心协力做国际一流的研究工作。

主要成果

    1. Yang, Y., Tan, Y.-Q., Wang, X., Li, J.-J., Du, B.-Y., Zhu, M., Wang, P., and Wang, Y.-F*. (2024). OPEN STOMATA1 phosphorylates CYCLIC NUCLEOTIDE-GATED CHANNELs to trigger Ca2+ signaling for ABA-induced stomatal closure in Arabidopsis. Plant Cell, doi: 10.1093/plcell/koae073.

    2. Tan, Y.-Q., Yang, Y., Shen, X., Zhu, M., Shen, J., Zhang, W., Hu, H., and Wang, Y.-F*. (2023). Multiple cyclic nucleotide-gated channels function as ABA-activated Ca2+ channels required for ABA-induced stomatal closure in Arabidopsis. Plant Cell 35, 239-259.

    3. Huang, X., Zhang, X., An, N., Zhang, M., Ma, M., Yang, Y., Jing, L., Wang, Y., Chen, Z., and Zhang, P. (2023). Cryo-EM structure and molecular mechanism of abscisic acid transporter ABCG25. Nat Plants 9, 1709-1719.

    4. Yu, H., Yang, L., Li, Z., Sun, F., Li, B., Guo, S., Wang, Y.-F., Zhou, T., and Hua, J. (2022). In situ deletions reveal regulatory components for expression of an intracellular immune receptor gene and its co-expressed genes in Arabidopsis. Plant Cell  Environ, doi: 10.1111/pce.14293.

    5. Liu, H., Lin, J.S., Luo, Z., Sun, J., Huang, X., Yang, Y., Xu, J., Wang, Y.-F., Zhang, P., Oldroyd, G.E.D., and Xie, F. (2022). Constitutive activation of a nuclear-localized calcium channel complex in Medicago truncatula. Proc Natl Acad Sci U S A 119, e2205920119.

    6. Tan Y-Q, Yang Y, Zhang A, Fei C-F, Gu LL, Sun SJ, Xu W, Wang L, Liu H, and Wang Y-F*. (2019). Three CNGC family members, CNGC5, CNGC6, and CNGC9, are required for constitutive growth of Arabidopsis root hairs as Ca2+-permeable channels. Plant Com, doi: https://doi.org/10.1016/j.xplc.2019.100001.

    7. Wang J, Liu X, Zhang A, Ren Y, Wu F, Wang G, Xu Y, Lei C, Zhu S, Pan T, Wang Y, Zhang H, Wang F, Tan Y-Q, Wang Y, Jin X, Luo S, Zhou C, Zhang X, Liu J, Wang S, Meng L, Wang Y, Chen X, Lin Q, Zhang X, Guo X, Cheng Z, Wang J, Tian Y, Liu S, Jiang L, Wu C, Wang E, Zhou J-M, Wang Y-F, Wang H, Wan J*. (2019). A cyclic nucldotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice. Cell Res, doi: 10.1038/s41422-019-0219-7.

    8. Tan Y-Q, Sun S-J, Xu W, Wang L, and Wang Y-F*. (2019). Advances in plasma membrane ion channels of plant cells. Chin Bull Bot 54(1), 102-118.

    9. Qi G-N, Yao F-Y, Ren H-M, Sun S-J, Hussain J, and Wang Y-F*. (2018). Constitutive activation of calcium-dependent protein kinase 3 confers a drought tolerance by inhibiting inward K+ channel KAT1 and stomatal opening in Arabidopsis. Sci Bull 63, 1037-1039.

    10. Yao L, Cheng X, Gu Z, Huang W, Li S, Wang L, Wang Y-F, Xu P, Ma H, and Ge X. (2018). The AWPM-9 family protein OsPM1 mediates abscisic acid influx and drought response in rice. Plant Cell 30(6): 1258-1276.

    11. Qi G-N, Yao F-Y, Ren H-M, Sun S-J, Tan Y-Q, Zhang Z-C, Qiu B-S, and Wang Y-F*. (2018). S-type anion channel ZmSLAC1 plays essential roles in stomatal closure by mediating nitrate efflux in maize. Plant Cell Physiol 59, 614-623.

    12. Yao F-Y, Qi G-N, Ren, H-M, Zhang A, Jamshaid H, and Wang Y-F*. (2017). S-type anion channel SLAC1’s homologues inhibit inward potassium channels AKT2 and KAT2 in Arabidopsis. Sci Bull 62: 464-466.

    13. Zhang A, Ren H-M, Tan Y-Q, Qi G-N, Yao F-Y, Wu G-L, Yang L-W, Hussain J, Sun S-J, Wang Y-F*. (2016). S-type anion channels SLAC1 and SLAH3 function as essential negative regulators for K+ channel KAT1 and stomatal opening in Arabidopsis. Plant Cell 28:949-965.

    14. Gao Q-F, Gu L-L, Wang H-Q, Fei C-F, Xiang F, Hussain J, Sun S-J, Dong J-Y, Liu H, Wang Y-F*. (2016). Cyclic nucleotide-gated channel 18 is an essential Ca2+ channel in pollen tube tips for pollen tube guidance to ovules in Arabidopsis. Proc Natl Acad Sci USA 113: 3096-3101.

    15. Gu L-L, Gao Q-F, and Wang Y-F*. (2016). Cyclic nucleotide-gated channel 18 is essential for pollen germination and tube growth in Arabidopsis. Plant Signal Behav, doi: 10.1080/15592324.2016.1197999.

    16. Sun S-J, Qi G-N, Gao Q-F, Wang H-Q, Yao F-Y, Hussain J, and Wang Y-F*. (2016). Protein kinase OsSAPK8 functions as an essential activator of S-type anion channel OsSLAC1, which is nitrate-selective in rice. Planta 243: 489-500

    17. Gao Q-F, Fei C-F, Dong J-Y, Gu L-L, and Wang Y-F*. (2014). Arabidopsis CNGC18 is a Ca2+-permeable channel. Mol Plant 7: 739-743.

    18. Wang Y-F*, Munemasa S, Nishimura N, Ren H-M, Robert N, Han M, Puzorjova I, Kollist H, Lee S, Mori I, Schroeder JI*. (2013). Identification of cyclic GMP-activated nonselective Ca2+-permeable cation channels and associated CNGC5 and CNGC6 genes in Arabidopsis guard cells. Plant Physiol 163: 578-590.

    19. Laanemets K, Wang Y-F (co-first author), Lindgren O, Wu J, Nishimura N, Lee S, Caddell D, Merilo E, Brosche M, Kilk K, Soomets U, Kangasjarvi J, Schroeder JI, Kollist H*. (2013). Mutations in the SLAC1 anion channel slow stomatal opening and severely reduce K+ uptake channel activity via enhanced cytosolic [Ca2+] and increased Ca2+ sensitivity of K+ uptake channels. New Phytol 197: 88-98.

    20. Vahisalu T, Kollist H, Wang Y-F(co-first author), Nishimura N, Chan WY, Valerio G, Lamminmaki A, Brosche M, Moldau H, Desikan R, Schroeder JI, Kangasjarvi J*. (2008). SLAC1 is required for plant guard cell S-type anion channel function in stomatal signalling. Nature 452: 487-491.