Education Background & Academic Experience：
2004-2008 B.S. in biology, China Agricultural University, College of Biological Sciences
2008-2014 Ph.D. in plant biology, Michigan State University (USA), DOE-Plant Research Laboratory
2014-2017 Post-doc, Michigan State University (USA), DOE-Plant Research Laboratory
2017- Principal Investigator, Institute of Plant Physiology and Ecology, Shanghai, CAS
CAS-JIC Center of Excellence for Plant and Microbial Science
Plants in nature are in constant contact with microbes, including pathogens, symbionts and commensal microbes, during any stage of development, and these contacts could greatly influence important plant traits such as growth and disease resistance. Dr. Xin’s group study plant-microbe interactions, working with the model system Arabidopsis thaliana-Pseudomonas syringae as well as diseases on the important crop species rice, and carry out research in the following two areas: 1. Plant-pathogen interactions, focusing on bacterial pathogenesis, interplay between host immunity and pathogen virulence mechanisms and environmental regulation of plant diseases; 2. Plant- microbiome interactions, focusing on the mechanisms of how plants control a “healthy” and balanced phyllosphere microbiome and how the homeostasis of the phyllosphere microbiome contributes to basic plant health.
1. Major IT, Yoshida Y, Campos ML, Kapali G, Xin XF, Sugimoto K, de Oliveira Ferreira D, He SY, Howe GA. (2017) Regulation of growth-defense balance by the JAZ-MYC transcriptional module. New Phytol. accepted
2. Xin XF, Nomura K, Aung K, Velásquez AC, Yao J, Boutrot F, Chang JH, Zipfel C, He SY (2016) Bacteria establish an aqueous living space in plants crucial for virulence. Nature 539: 524-529.
-Featured in the News sections of Nature;
-Commented by Dev. Cell and Cell Systems;
-Recommended by F1000Prime;
3. Zhao Y, Huang J, Wang Z, Jing S, Wang Y, Ouyang Y, Cai B, Xin XF, Liu X, Zhang C, Pan Y, Ma R, Li Q, Jiang W, Zeng Y, Shangguan X, Wang H, Du B, Zhu L, Xu X, He SY, Feng YQ, Chen R, Zhang Q, He G. (2016) Allelic diversity in an NLR gene BPH9 enables rice to combat planthopper variation. Proc. Natl. Acad. Sci. USA, 113:12850-5.
4. Xin XF, Nomura K, Ding X, Aung K, Chen X, Wang K, Uribe F, Yao J, Chen J, He SY (2015) Pseudomonas syringae effector AvrE localizes to the host plasma membrane and down-regulates the expression of the NDR/HIN1-like 13 gene required for antibacterial immunity in Arabidopsis. Plant Physiol.169:793-802.
5. Zhang L, Yao J, Withers J, Xin XF, Banerjee R, Fariduddin Q, Nakamura Y, Nomura K, Howe GA, Boland W, Yan H, He SY (2015) Host target modification as a strategy to counter pathogen hijacking of the jasmonate hormone receptor. Proc. Natl. Acad. Sci. USA 112:14354-9.
6. Zhang F, Yao J, Ke J, Zhang L, Lam VQ, Xin XF, Zhou E, Chen J, Brunzelle J, Griffin PR, Zhou M, Xu E, Melcher K , He SY (2015) Structural basis of JAZ-mediated repression of MYC transcription factors in jasmonate signaling. Nature 525:269-73.
7. Guo L-B, Qiu J, Han Z, Ye Z, Chen C, Liu C, Xin XF, Y C, Wang Y-Y, Xie H, Wang Y, Bao J, Tang S, Xu J, Gui Y, Fu F, Wang W, Zhang X, Zhu Q, Guang X, Wang C, Cui H, Cai D, Ge S, Tuskan G, Yang X, Qian Q, He SY, Wang J, Zhou X, Fan L. (2015) A host plant genome after century-long endophyte infection. Plant J. 83:600-9.
8. Xin XF, He SY (2013) Pseudomonas syringae pv. tomato DC3000: A model pathogen for probing disease susceptibility and hormone signaling in plants. Annu. Rev. Phytopathol. 51:473-98.
9. Xin XF, Underwood W, Nomura K, He SY (2013) Induction and suppression of PEN3 focal accumulation during Pseudomonas syringae pv. tomato DC3000 infection of Arabidopsis. Mol. Plant Microbe Interact. 26:861-7.
10. Yang Q, Chen ZZ, Zhou XF, Yin HB, Li X, Xin XF, Hong XH, Zhu JK, Gong Z (2009) Overexpression of SOS (Salt Overly Sensitive) genes increases salt tolerance in transgenic Arabidopsis. Mol. Plant 2:22–31.
11. Aung K, Xin XF, Mecey C, He SY (2016) Subcellular localization of Pseudomonas syringae pv. tomato effector proteins in plants. Type 3 Secretion Systems: Methods and Protocols 141-153. (Methods in Molecular Biology; Springer New York; book chapter)