YONG WANG Ph.D., Professor Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200031, China. Tel: 54924295; Email: yongwang@sibs.ac.cn

Research Interests:
Our research is centered on the design and assembly of recombinant microorganisms for the production of complex natural products. More simply, we are harnessing the synthetic power of biology to build microbial factories. Current efforts include the isolation and identification of different gene/module/pathway resources, development of tools and methodologies for novel biosynthetic pathway design and the natural products heterologous biosynthesis in the engineered microbes. A particular focus is the elucidation of design principles for the production of unnatural natural compounds within the framework of the nascent field of synthetic biology.

Publications:

1. Feifei Chen, Yong Wang, Yiguang Wang, Weiqing He. Distribution and diversity of glycosylated natural product genes in marine bacteria genomes. Applied Microbiology and Biotechnology. 2011, 90(4):1347

2. Hailin Meng, Yong Wang, Siliang Zhang, Xiaoning wang. In silico analysis and experimental improvement of the terpenoid precursor supply pathways for taxadiene heterologous biosynthesis in Escherichia coli. Biotechnology and Bioprocess Engineering. 2011, 16 (2): 205

3. Zhang H, Wang Y, Wu J, Skalina K, Pfeifer BA. Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host. Chem Biol. 2010 17(11):1232-40

4. Ajikumar, P.K., Xiao, W.-H., Tyo, K.E.J., Wang, Y., Simeon, F., Leonard, E., Mucha, O., Phon, T.H., Pfeifer, B., and Stephanopoulos, G. Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli. Science. 2010, 330, 70-74.

5. Yong Wang, Yingping Zhuang, Ping Wang, Ju Chu, Siliang Zhang. Regulation of meilingmycin in Streptomyces nanchangensis: effect of ammonium ion. Korean J Chem Eng. 2009. 27(3), 910

6. Yong Wang, Ju Chu, Yingping Zhuang, Yonghong Wang, Jianjie Xia, Siliang Zhang. Industrial bioprocess control and optimization in the context of systems biotechnology. Biotechnology Advances. 2009. 27(6): 989-995

7. Hui Hu, Jiangchao Qian, Ju Chu, Yong Wang, Yingping Zhuang, Siliang Zhang. DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-L-methionine production in Pichia pastoris. J Biotechnol. 2009, 141(3-4): 97-103.

8. Haoran Zhang, Yong Wang, Brett Boghigian, Blaine Pfeifer. Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in E. coli. Microbial Biotechnol. 2009. 2, (3): 390

9. Yong Wang, Blaine Pfeifer. 6-Deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli. Metabolic Engineering. 2008, 10 (1):33

10. Yong Wang, Yiguang Wang, Ju Chu, Siliang Zhang. High frequency transformation of the industrial erythromycin-producing bacterium Saccharopolyspora erythraea. Biotechnology letters. 2008, 30(2):357

11. Yong Wang, Saba Parsa, Jason Fuller, Robert Langer, and Blaine A. A Comparison between Polymeric Microsphere and Bacterial Vectors for Macrophage P388D1 Gene Deliver. Pharmaceutical Research. 2008, 25 (5), 1202

12. Yong Wang, Haoran Zhang, Pfeifer BA. Bacterial hosts for natural product production. Molecular Pharmaceutics. 2008, 5 (2): 212

13. Yuhong Ren, Yong Wang, Yufei Zhang, Dongzhi Wei. Overcoming multidrug resistance in a human carcinoma cells by an antisense oligodeoxynucleotide-doxorubicin conjugate in vitro and in vivo. Molecular Pharmaceutics. 2008, 5(4):579

14. Yong Wang, Saba Parsa, Katie Rines, and Blaine Pfeifer. A high-throughput comparison of recombinant gene expression parameters for E. coli-mediated gene transfer to P388D1 macrophage cells. Journal of Biotechnology. 2008 ,137(1-4):59-64

15. Yong Wang, Brett Blaine Pfeifer. Improving heterologous polyketide production in Escherichia coli by over-expression of an S-adenosylmethionine synthetase gene. Applied Microbiology and Biotechnology. 2007, 77(2):367

16. Yong Wang, Yiguang Wang, Ju Chu, Yingping Zhuang, Lixin Zhang, Siliang Zhang. Improved production of erythromycin A by expression of a heterologous gene encoding S-adenosylmethionine synthetase. Applied Microbiology and Biotechnology. 2007, 75(4): 837

Address: 300 Feng Lin Road, Shanghai 200032, China
Tel: 86-21-54924000        Fax: 86-21-54924015        Email: webmaster@sippe.ac.cn