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 The maintenance of genome integrity and fidelity is essential for the proper function and survival of all organisms. The insect is particularly daunting due to constant assault on the DNA by genotoxic agents, including different species of insecticides. Failure to repair DNA lesions may result in blockages of transcription and replication, mutagenesis, and cytotoxicity. The mutations that result in insecticide resistance in various species of insects are rare and perhaps unique events under natural selection. Our studies are focusing on dissecting the mechanisms of insect DNA damage responses to insecticidal toxicity.
Education Background & Academic Experience
Education:
1988 September: M.D. Anhui College of Traditional Chinese Medicine, Hefei, China
1998 September: PhD, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Academic experience:
2002 March Visiting Scientist, UNIVERSITE PAUL SABATIER DE TOULOUSE III, Toulouse, France
2003 March: Visiting Scientist, Protein Biophysics and Biotechnology Group. Institute of Pharmacology and Structural Biology, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Toulouse, France
2003 November: Postdoctoral Research Associate, Stowers Institute for Medical Research, Kansas City, USA
2007 November: Senior Research Associate, Stowers Institute for Medical Research, Kansas City, USA
2009 April: Principal Investigator, Professor, Institute of Plant Physiology and Ecology, Institutes for Biological Sciences, Chinese Academy of Sciences, China
Selected Publications
Shi MA, Vivian CJ, Lee KJ, Ge CM, Morotomi-Yano K, Manzl C, Bock F, Sato S, Tomomori-Sato C, Zhu RH, Haug JS, Swanson SK, Washburn MP, Chen DJ, Chen BPC, Villunger A, Florens L, and Du CY (2009) DNA-PKcs-PIDDosome: A Nuclear Caspase-2-Activating Complex with Role in G2/M Checkpoint Maintenance. Cell, 136 (3):508-520. Tao LM , Shi MA, Yuang JZ, Zhuang PJ, Zhang CX, and Tang ZH (2006) Resistance pattern and point mutations of insensitive acetylcholinesterase in a carbamate-resistant strain of housefly (Musca domestica). Pesticide Biochemistry Phsiololgy, 86(1):1-6. Ren JY, Shi MA, Liu RS, Yang QH, Johnson T, Skarnes W, and Du CY (2005) The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development. Proc Natl Acad Sci USA, 102(2): 565-570. Menozzi P*, Shi MA*, Lougarre A, Tang ZH, and Fournier D (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster populations. BMC Evol Biol, 4(1): 4. (*, Co-first authors) Shi MA, Lougarre A, Alies C, Frémaux I, Tang ZH, Stojan J, and Fournier D (2004) Acetylcholinesterase alterations reveal the fitness cost of mutations conferring insecticide resistance. BMC Evol Biol, 4(1): 5. Shi MA, Lougarre A, Alies C, Frémaux I, and Fournier D (2004) Engineering of acetylcholinesterase for insecticide detection: example of aldicarbe. In "Cholinesterase in the second millenium, Biomolecular and pathological aspects", 237-241. (paper in conference book) Inestrosa and Campos eds. Disenoe Impresiones J&J tda. Shi MA, Yuan JZ, Wu J, Zhuang PJ, Wu XF, and Tang ZH (2002) Kinetic analysis of acetylcholinesterase in a propoxur-resistant strain of housefly (Musca domestica) from Shanghai, China. Pesticide Biochemistry Phsiolology, 72(2): 72-82. Shi MA, Yuan JZ, Wu J, Zhuang PJ, and Tang ZH (2001) Studies on the kinetics of acetylcholinesterase in the resistant and susceptible strain of housefly (Musca domestica). Insect Science (formerly Entomologia Sinica), 8(1): 30-38.
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